Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury

KUMRAL A., Tuzun F., TUĞYAN K., ÖZBAL S., YILMAZ O., Yesilirmak C. D., ...More

EARLY HUMAN DEVELOPMENT, vol.89, no.3, pp.165-173, 2013 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 89 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.earlhumdev.2012.09.016
  • Journal Name: EARLY HUMAN DEVELOPMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.165-173
  • Keywords: Newborn, Hypoxic-ischemia, Epigenetic, DNA methylation, Histone methylation, Gene expression, Rat, Apoptosis, Angiogenesis
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: DNA methylation and histone modifications are the most identified modifications that selectively activate or inactivate genes that control cell growth, proliferation, and apoptosis.