An electrochemical DNA biosensor for the detection of DNA damage caused by radioactive iodine and technetium

Kara P., Dagdeviren K., Oezsoez M.

TURKISH JOURNAL OF CHEMISTRY, vol.31, no.3, pp.243-249, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2007
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.243-249
  • Keywords: Electrochemistry, DNA damage, Tc-99m, iodine-131, CARBON ELECTRODES, HYBRIDIZATION, GUANINE, OXIDATION
  • Dokuz Eylül University Affiliated: No

Abstract

A DNA damage process by radioactive iodine (I-131) and technetium (Tc-99m) is described. The procedure relies on a label-free electrochemical DNA biosensor. Fish sperm double stranded DNA was immobilized onto a carbon paste electrode (CPE) by electro deposition and the changes to the guanine oxidation signal were observed upon exposure to radioactive I-131 and Tc-99m by differential pulse voltammetry (DPV).