Effect of Vitamin D on Cognitive Functions in Older Adults: 24-Week Follow-Up Study

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Bulut E. A., Soysal P., YAVUZ İ., Kocyigit S. E., IŞIK A. T.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, vol.34, no.2, pp.112-117, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.1177/1533317518822274
  • Journal Name: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.112-117
  • Keywords: vitamin D deficiency, cognitive decline, dementia, D DEFICIENCY, 1,25-DIHYDROXYVITAMIN D-3, ORTHOSTATIC HYPOTENSION, MUSCLE STRENGTH, D-RECEPTOR, DISEASE, POPULATION, IMPAIRMENT, DEMENTIA, RISK
  • Dokuz Eylül University Affiliated: Yes

Abstract

The purpose of this study is to assess the effect of vitamin D replacement on cognitive function in older adults. A total of 560 patients who underwent comprehensive geriatric assessment including Global cognitive assessment, Basic Activities of Daily Living (BADL), and Instrumental Activities of Daily Living (IADL) twice in 6-month period were retrospectively reviewed. Oral cholecalciferol was replaced to patients with vitamin D deficiency routinely. In baseline cognitive scores, BADL-IADL scores were lower in the severe deficiency group than in the deficiency and adequate groups (P < .05). With regard to the relation between changes in cognitive functions, BADL-IADL scores on the 6-month versus baseline, no difference was determined in patients with and without dementia (P > .05). Vitamin D replacement may not improve cognitive performance in older adults, even if vitamin D is raised to adequate level, suggesting that longer term replacement therapy may be needed to improve cognitive function.