Akademik Veri Yönetim Sistemi
IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, cilt.15, sa.1, ss.7-13, 2025 (Hakemli Dergi)
ABSTRACT
Objective: Childhood cancers constitute 2% of all cancers seen in the world. Overall 5-year survival rate for
childhood cancers is 80% in developed, but it is only 30% in underdeveloped countries. In our study have we aimed
to analyze the childhood cancer cases treated in our hospital, and to compare the epidemiological characteristics
of the patients followed in our center, the distribution of cancer types in our center and the overall survival rates,
with the data obtained from our national, and international literature.
Method: The records of patients aged 0-19 years with lymphomas and malignant solid tumors, who were followed
up and treated between December 25,1987 and January 28, 2021 in our department of pediatric oncology were
examined. Hospital files of 1326 patient were reviewed retrospectively, and 1175 patients were included in the
study. The data were analyzed in SPSS 25.0 package program.
Results: In our study, the male/female ratio was 1.2 among 1175 patients diagnosed with lymphoma and malignant
solid organ tumor with a mean age of 7.75 years at the time of diagnosis. Considering the subgroup distribution
of childhood cancers other than leukemias; central nervous system tumors (23.6%), lymphomas (19.5%) and
neuroblastomas (12%) were found to be the most common malignant diseases. The mean follow-up time of our
patients was 62.31±55.3 months, and the mean event-free follow-up period was 50.20±49.681 months. Five- and
10-year overall survival, and event-free survival rates were 74% vs. 68.9%, and 50.5%, vs. 39%, respectively.
Conclusion: In general, survival rates in childhood cancers in our center are close to the average of our region,
our country and European countries, but it was found to be lower in some subgroups of our patients compared
to developed countries.
Keywords: Childhood cancers, epidemiology, overall survival rate, event-free survival rate