Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer

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Çalıbaşı Koçal G., Pakdemirli A., Bayrak S., Ozupek N., Sever T., Başbınar Y., ...Daha Fazla

JOURNAL OF BUON, cilt.24, sa.4, ss.1482-1487, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2019
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1482-1487
  • Anahtar Kelimeler: colorectal cancer, curcumin, invasion, migration, proliferation
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, wound healing, anti-invasive and anti-migrative effects of curcumin on HCT-116 and LoVo colorectal cancer cell lines. Methods: The antiproliferative activity of 2.5-75 mu M curcumin was tested on HCT-116 and LoVo colorectal cell lines and the viability of the cells was tested with WST-1 reagent by using ELISA plate reader at 450 nm. xCELLigence RTCA DP system was used for the detection of anti-invasive and anti-migrative effects of curcumin. Results: The IC50 of curcumin was 10 +/- 0.03 for HCT-116 and 20 +/- 0.05 mu M for LoVo cell lines. The IC50 of curcumin (10 mu M for HCT-116 and 20 mu M for LoVo) showed anti-metastatic activity on these cell lines. Conclusion: This study showed that curcumin could be evaluated as a promising anti-cancer agent for human colorectal cancer.