Molecular and Biochemical Parameters Related to Plasma Mannose Levels in Coronary Artery Disease Among Nondiabetic Patients


KÖSELER A., Arslan I., Sabirli R., ZEYTÜNLÜOĞLU A., Kilic O., Kilic I. D.

GENETIC TESTING AND MOLECULAR BIOMARKERS, vol.24, no.9, pp.562-568, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.1089/gtmb.2020.0095
  • Journal Name: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.562-568
  • Keywords: coronary vascular disease (CAD), plasma mannose level, nondiabetic, insulin, ALPHA-D-MANNOSE, INSULIN-RESISTANCE, GLUCOSE TRANSPORTERS, GENE-EXPRESSION, HEART, HEXOKINASE, GLUT4, SENSITIVITY, SKELETAL
  • Dokuz Eylül University Affiliated: No

Abstract

Aims:Nondiabetic patients were studied to determine whether modest elevations in plasma mannose may be associated with a greater incidence of coronary artery disease (CAD). Materials and Methods:Plasma insulin, mannose, glucose, hexokinase 1-2, GLUT1-GLUT4 levels, and serum mannose phosphate isomerase enzyme levels were evaluated with respect to subsequent CAD using records from 120 nondiabetic CAD patients and 120 healthy volunteers. CAD was identified from myocardial infarction and new diagnoses of angina. Results:Of 120 nondiabetic CAD patients studied, their plasma GLUT4 and HK1 levels were significantly lower than those of the control group. A significant increase in plasma mannose levels was found in the patient group compared to the control group. Conclusion:Our findings showed that elevated baseline mannose levels in plasma are associated with an increased risk of CAD over time.