Akademik Veri Yönetim Sistemi
The 9th Joint ECTRIMS-ACTRIMS Meeting, Milan, İtalya, 11 - 13 Ekim 2023, ss.698, (Özet Bildiri)
Introduction: Early-onset multiple sclerosis (MS, EOMS) and very early-onset MS (VEOMS) are less common than adult-onset MS (AOMS). Moreover, there is limited information regarding EOMS and VEOMS prognosis compared with AOMS.Objectives/Aims: The aim was to assess and compare cognitive and physical functions between people with EOMS, VEOMS, and AOMS.Methods: People with EOMS (initial age between 18-12) (n=61), people with VEOMS (initial age between⩽12 years) (n=30), and age-, gender-, and type of MS-matched people with AOMS (initial age between 18-50 years) (n=97) were included. Cognitive func-tions were assessed with the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery, which included the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2), and the Brief Visuospatial Memory Test-Revised (BVMT-R). The upper extremity function was assessed using the Nine-Hole Peg Test (N-HPT). The Timed 25-Foot Walk Test (T25FW) and Timed up Go (TUG) were used to assess lower extremity function. Expanded Disability Status Scale (EDSS), disease duration, and number of relapses were recorded.Results: There was a significant difference in disease duration and number of relapses between the three groups (disease duration: EOMS=12.44±8.03, VEOMS=19.46±10.74, AOMS=4.86±5.97, p<0.001; the number of relapses: EOMS=4.57±2.58, VEOMS=4.80±2.50, AOMS=2.89±2.42, p<0.001). The post-hoc analyses revealed that people with VEOMS, as expected, have longer dis-ease durations than people with AOMS (p<0.001) and EOMS (p=0.009), while people with AOMS have shorter disease duration than EOMS (p<0.001). Also, the relapse number was significantly less in the AOMS group than in the EOMS (p<0.001) and the VEOMS (p=0.001) groups. However, there were no significant differences between the three groups regarding EDSS score, cog-nitive functions, and upper and lower extremity performance (p>0.05).Conclusion: This study pointed to two significant results. First, disease duration and the number of relapses are not the certain parameters that negatively affect cognitive and physical functions in people with MS. Second, if the disease process is managed suc-cessfully, people with EOMS and VEOMS show the same cogni-tive and physical performance as people with AOMS.