Although climate change directly affects air temperature, humidity or other weather conditions, there are many areas where indirect effects are also observed. Endurance in food production cannot be achieved in agricultural areas where drought or excessive precipitation is observed due to climate change. Therefore, sustainable, or controllable agriculture becomes very important. Greenhouses are simple buildings used for sustainable and controllable agriculture. However, adjusting the greenhouse indoor environment for efficient and sustainable food production is a complex problem. In this study, a dynamic simulation model was designed for the heating, cooling and ventilation of a greenhouse and annual simulations were taken in İzmir conditions. The developed HVAC system consists of a heating coil with humidifying, a cooling coil with dehumidifying, a fan and a transient thermal greenhouse model which is developed in MATLAB and implemented into TRNSYS software. Also, the growth of the tomato crop is implemented into greenhouse thermal model. The aim of the HVAC system in the developed dynamic simulation model is to keep the greenhouse inside temperature and relative humidity in range of optimum tomato growth. The optimum temperature for tomato growth is presented in the literature between 24℃ and 26℃, also the optimum relative humidity of greenhouse inside air is presented between 40% and 60%. The simulation results shows that the annual average greenhouse inside temperature was 24.26℃, the humidity ratio of the inside air was 0.0089 kgH2O/kg-Dry-Air and the average relative humidity of the greenhouse inside was 47.64% in İzmir.