Life-threatening mediastinal-retroperitoneal hemorrhage in a child with moderate hemophilia A and high inhibitor titer: Successful management with recombinant activated factor VII

YILMAZ Ş., ÖREN H., Irken G., Atabay B., DUMAN M., YILMAZ E., ...Daha Fazla

Journal of Pediatric Hematology/Oncology, cilt.27, sa.7, ss.400-402, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 27 Sayı: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1097/01.mph.0000174241.03038.b5
  • Dergi Adı: Journal of Pediatric Hematology/Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.400-402
  • Anahtar Kelimeler: Factor VIII inhibitor, Hemophilia A, Mediastinal and retroperitoneal bleeding, Recombinant activated factor VII
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The authors describe an 11-year-old boy with hemophilia A and high titer inhibitor who developed a life-threatening mediastinal-retroperitoneal hemorrhage. Chest CT showed a large hematoma beginning in the retrotracheal area, filling the mediastinum, compressing the carina, and extending retroperitoneally up to the kidneys. As the surgical approach has a high mortality rate, the authors chose a more conservative approach initially and obtained excellent bleeding control with recombinant activated factor VII without the need for surgical intervention. As reported in other patients, the authors also showed a decrease in the factor III inhibitor while this patient was successfully treated with bypassing agents. Copyright © 2005 by Lippincott Williams & Wilkins.