Stereological evaluation of the volume and volume fraction of intracranial structures in magnetic resonance images of patients with Alzheimer's disease.

Bas O., Acer N., Mas N. N., Karabekir H. S., Kusbeci O. Y., Sahin B.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, vol.191, no.2, pp.186-95, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 191 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.aanat.2008.12.003
  • Journal Name: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.186-95
  • Keywords: Cavalieri principle, Volume estimation, Volume ratio, Magnetic resonance imaging, Stereology, Alzheimer, TEMPORAL-LOBE, CAVALIERI PRINCIPLE, NORMATIVE VALUES, CEREBRAL ATROPHY, LIVER VOLUME, SERIAL MRI, MORPHOLOGY, CARCINOMA, COMBINATION, MORPHOMETRY
  • Dokuz Eylül University Affiliated: No

Abstract

In this study, we describe and adapt the relevant methods of magnetic resonance (MR) and stereology to estimate total brain volume (TBV), cerebral and cerebellar volume and their volume fractions within the brain. The study included 15 (8 males, 7 females) controls and 15 (8 males, 7 females) patients with Alzheimer's disease. The patients MR images were obtained in both sagittal and axial planes. The volume and volume fraction of the total brain, cerebrum and cerebellum were determined on MR images using the point-counting approach of stereological methods.