The protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in rats

Gencer B., KARACA T., Tufan H. A., Kara S., Arikan S., Toman H., ...More

CUTANEOUS AND OCULAR TOXICOLOGY, vol.33, no.4, pp.283-288, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.3109/15569527.2013.857677
  • Journal Name: CUTANEOUS AND OCULAR TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.283-288
  • Keywords: Apoptosis, dexmedetomidine, retinal ischemia/reperfusion injury, ISCHEMIA-REPERFUSION INJURY, CEREBRAL-ISCHEMIA, GLUTAMATE RELEASE, AGONIST, MODEL, DAMAGE, NEUROTOXICITY, DEGENERATION, PATHOGENESIS, EXPRESSION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Dexmedetomidine is an alpha 2 adrenoceptor agonist and can be used for postoperative sedation, analgesia and anesthesia-sparing properties. Furthermore, the neuroprotective effects against ischemia/reperfusion (I/R) injury in the central nervous system have been shown in experimental studies. This study aimed to investigate the protective effects of dexmedetomidine against apoptosis in retinal I/R injury in the rat.