The frequencies of c-kit proto-oncogene (KIT) mutations in gastrointestinal stromal tumours: a population based study from Aegean Region of Turkey

ÇALIBAŞI KOÇAL G., BAŞBINAR Y., ÖZTOP İ., SAĞOL Ö., ATİLA K., ELLİDOKUZ H., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.38, no.1, pp.5-12, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5505/tjb.2013.29981
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.5-12
  • Keywords: Gastrointestinal stromal tumors, KIT gene mutations, DNA sequencing, pharmacogenomics, RECEPTOR-ALPHA MUTATIONS, PROGNOSTIC VALUE, POOR-PROGNOSIS, PRIMARY SITE, IMATINIB, PDGFRA, GISTS, ASSOCIATION, ACTIVATION, MORPHOLOGY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: The c-kit proto-oncogene (KIT) exon 9, 11, 13 and 17 activation mutations are associated with clinical behaviour in gastrointestinal stromal tumors with highly variable biological behaviour. The purpose of this study is to determine the frequency of KIT gene exon 9, 11, 13 and 17 mutations and associate them with histopathologic features for the first time in the Turkish population.