The frequencies of c-kit proto-oncogene (KIT) mutations in gastrointestinal stromal tumours: a population based study from Aegean Region of Turkey

ÇALIBAŞI KOÇAL G., BAŞBINAR Y., ÖZTOP İ., SAĞOL Ö., ATİLA K., ELLİDOKUZ H., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.38, sa.1, ss.5-12, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5505/tjb.2013.29981
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.5-12
  • Anahtar Kelimeler: Gastrointestinal stromal tumors, KIT gene mutations, DNA sequencing, pharmacogenomics, RECEPTOR-ALPHA MUTATIONS, PROGNOSTIC VALUE, POOR-PROGNOSIS, PRIMARY SITE, IMATINIB, PDGFRA, GISTS, ASSOCIATION, ACTIVATION, MORPHOLOGY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: The c-kit proto-oncogene (KIT) exon 9, 11, 13 and 17 activation mutations are associated with clinical behaviour in gastrointestinal stromal tumors with highly variable biological behaviour. The purpose of this study is to determine the frequency of KIT gene exon 9, 11, 13 and 17 mutations and associate them with histopathologic features for the first time in the Turkish population.