Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE)

Hermans, Lucas; Svicher, Valentina; Pas, Suzan; Salpini, Romina; Alvarez, Marta; Ben Ari, Ziv; Boland, Greet; Bruzzone, Bianca; Coppola, Nicola; Seguin-Devaux, Carole; Dyda, Tomasz; Garcia, Federico; Kaiser, Rolf; Kose, ŞÜKRAN; Krarup, Henrik; Lazarevic, Ivana; Lunar, Maja; Maylin, Sarah; Micheli, Valeria; Mor, Orna; Paraschiv, Simona; Paraskevis, Dimitrios; Poljak, Mario; Puchhammer-Stoeckl, Elisabeth; Simon, Francois; Stanojevic, Maja; Stene-Johansen, Kathrine; Tihic, Nijaz; Trimoulet, Pascale; Verheyen, Jens; Vince, Adriana; Weis, Nina; Yalcinkaya, Tulay; Lepej, Snjezana; Perno, Carlo; Boucher, Charles; Wensing, Annemarie

doi:10.1093/infdis/jiv363

Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE)

Hermans L. E., Svicher V., Pas S. D., Salpini R., Alvarez M., Ben Ari Z., ...More

JOURNAL OF INFECTIOUS DISEASES, vol.213, no.1, pp.39-48, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 213 Issue: 1
Publication Date: 2016
Doi Number: 10.1093/infdis/jiv363
Journal Name: JOURNAL OF INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.39-48
Keywords: antiviral drug resistance, genotypic resistance testing, hepatitis B virus, nucleos(t)ide analogs
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: No

Abstract

European guidelines recommend treatment of chronic hepatitis B virus infection (CHB) with the nucleos(t)ide analogs (NAs) entecavir or tenofovir. However, many European CHB patients have been exposed to other NAs, which are associated with therapy failure and resistance. The CAPRE study was performed to gain insight in prevalence and characteristics of NA resistance in Europe.