Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome

Temiz T., Demir O., Simsek F., Kaplan Y. C., Bahçeci S., Karadas B., ...More

INDIAN JOURNAL OF PHARMACOLOGY, vol.48, no.4, pp.424-429, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.4103/0253-7613.186189
  • Journal Name: INDIAN JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.424-429
  • Keywords: Distal colon, immunohistochemistry, irritable bowel syndrome, nitric oxide synthase, NITRIC-OXIDE SYNTHASE, VISCERAL HYPERSENSITIVITY, IN-VITRO, DISEASE, DIARRHEA, RECEPTOR, PAIN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: The aim of this study is to investigate whether nitric oxide (NO)-mediated colonic motility was altered in rat irritable bowel syndrome (IBS) model, using different isoforms of NO-synthase (NOS) inhibitors.