Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis

Yucel Z. P. K., Silbereisen A., EMİNGİL G., Tokgoz Y., Kose T., Sorsa T., ...More

JOURNAL OF PERIODONTOLOGY, vol.91, no.10, pp.1339-1347, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 91 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1002/jper.19-0415
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, DIALNET
  • Page Numbers: pp.1339-1347
  • Keywords: biomarkers, calprotectin, cystic fibrosis, gingivitis, saliva, TREM-1 protein, ORAL-HEALTH, CALPROTECTIN, STREM-1, PGLYRP1, MARKERS
  • Dokuz Eylül University Affiliated: No


Background Cystic fibrosis (CF) is a life-threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as a reservoir of bacterial colonization and potentially reflect systemic inflammation. This study investigated whether salivary triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1), interleukin (IL)-1 beta, and calprotectin are associated with CF or reflect concomitant gingival inflammation.