Future aspects of immunotherapy and gene therapy in neuroblastoma

AKTAŞ S.

Journal of B.U.ON., cilt.14, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 14
  • Basım Tarihi: 2009
  • Dergi Adı: Journal of B.U.ON.
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Gene therapy, Immunotherapy, Neuroblastoma
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Immunotherapy against cancer aims at stimulating the immune system or building an immune response against targeted tumor-associated antigens (TAAs). It was proposed theoretically as a potential therapy for cancer over a century ago but it became popular in the past two decades. Gene therapy represents a promising approach for reversing the neoplastic phenotype or driving tumor cells to self-destruction. Although survival rates of neuroblastoma (NB) with biologically favorable disease are greater than 90%, outcomes of patients with high risk disease are less than 40%. Stage 4 metastatic NB cases over 18 months of age are often incurable with multimodality chemotherapy regimens. In this article, translation of immuno-gene therapy strategies into clinical trials for NB are reviewed. Future aspects of immuno-gene therapy are discussed. © 2009 Zerbinis Medical Publications.