Relationship Between Dexamethasone Suppression Test Cortisol Level > 0.9 μg/dL and Depression and Quality of Life in Adrenal Incidentalomas: Single Centre Observational Case-Control Study Depression and Quality of Life in Adrenal Incidentalomas

Creative Commons License

Güneş M., Güneş E., Kaya M. İ., Küçükelyas H., Barut H., Öner S.

ENDOCRINE PRACTICE, vol.30, no.5, pp.1-8, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.1016/j.eprac.2024.05.002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.1-8
  • Dokuz Eylül University Affiliated: Yes


Objective: There has been increasing evidence that patients with adrenal incidentalomas (AIs) who have 1-mg dexamethasone suppression test (DST) cortisol levels >0.9 mg/dL may be exposed to the adverse consequences of hypercortisolaemia. We aim to evaluate whether there is a difference in Beck Depression Inventory-II (BDI-II) and quality of life (QoL) score in patients with AI based on the threshold of a DST cortisol level >0.9 mg/dL.

Methods: This case-control study included 42 nonfunctional adrenal incidentaloma (NFAI), 53 mild autonomic cortisol secretion (MACS) and 42 healthy controls (HCs). In addition, patients were categorized as 0.9 and >0.9 mg/dL according to their DST cortisol results.

Results: There was no difference in the QoL and BDI-II scores of MACS compared to NFAI. The BDI-II score was higher and QoL was lower in MACS and NFAI compared to HCs. The difference in QoL and BDI-II scores between MACS and NFAI remained insignificant when the DST cortisol levels threshold was graded upward (5.0 mg/dL). The prevalence of depression was higher in the AI >0.9 mg/dL group than the AI 0.9 mg/dL group (respectively, 16.7% and 55.8%, P 1⁄4 .003), BDI-II scores were higher in the AI >0.9 mg/dL group than in the AI 0.9 mg/dL group and HCs. The DST was an independent factor affecting the frequency of depression (odds ratio: 1.39, P 1⁄4 .037).

Conclusion: MACS and patients with NFAI had similar QoL and depression scores according to the 1.8 mg/dL and above, whereas, had lower QoL and higher depression scores according to the 0.9 mg/dL. © 2024 AACE. Published by Elsevier Inc. All rights are reserved, including those for text and data mining,

AI training, and similar technologies.