Relationship Between Dexamethasone Suppression Test Cortisol Level > 0.9 μg/dL and Depression and Quality of Life in Adrenal Incidentalomas: Single Centre Observational Case-Control Study Depression and Quality of Life in Adrenal Incidentalomas


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Güneş M., Güneş E., Kaya M. İ., Küçükelyas H., Barut H., Öner S.

ENDOCRINE PRACTICE, vol.30, no.5, pp.1-8, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.1016/j.eprac.2024.05.002
  • Journal Name: ENDOCRINE PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.1-8
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: There has been increasing evidence that patients with adrenal incidentalomas (AIs) who have 1-mg dexamethasone suppression test (DST) cortisol levels >0.9 mg/dL may be exposed to the adverse consequences of hypercortisolaemia. We aim to evaluate whether there is a difference in Beck Depression Inventory-II (BDI-II) and quality of life (QoL) score in patients with AI based on the threshold of a DST cortisol level >0.9 mg/dL.

Methods: This case-control study included 42 nonfunctional adrenal incidentaloma (NFAI), 53 mild autonomic cortisol secretion (MACS) and 42 healthy controls (HCs). In addition, patients were categorized as 0.9 and >0.9 mg/dL according to their DST cortisol results.

Results: There was no difference in the QoL and BDI-II scores of MACS compared to NFAI. The BDI-II score was higher and QoL was lower in MACS and NFAI compared to HCs. The difference in QoL and BDI-II scores between MACS and NFAI remained insignificant when the DST cortisol levels threshold was graded upward (5.0 mg/dL). The prevalence of depression was higher in the AI >0.9 mg/dL group than the AI 0.9 mg/dL group (respectively, 16.7% and 55.8%, P 1⁄4 .003), BDI-II scores were higher in the AI >0.9 mg/dL group than in the AI 0.9 mg/dL group and HCs. The DST was an independent factor affecting the frequency of depression (odds ratio: 1.39, P 1⁄4 .037).

Conclusion: MACS and patients with NFAI had similar QoL and depression scores according to the 1.8 mg/dL and above, whereas, had lower QoL and higher depression scores according to the 0.9 mg/dL. © 2024 AACE. Published by Elsevier Inc. All rights are reserved, including those for text and data mining,

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