Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action


Manchia M., Vieta E., Smeland O. B., Altimus C., Bechdolf A., Bellivier F., ...More

EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol.36, pp.121-136, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36
  • Publication Date: 2020
  • Doi Number: 10.1016/j.euroneuro.2020.05.006
  • Journal Name: EUROPEAN NEUROPSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.121-136
  • Keywords: Machine learning, Open science, Philanthropy, Precision medicine, Risk prediction, GENOME-WIDE ASSOCIATION, PSYCHIATRIC-DISORDERS, SUGGESTIVE LINKAGE, LITHIUM TREATMENT, I DISORDER, ONSET, SCHIZOPHRENIA, PSYCHOSIS, FRAMEWORK, CARE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus that the accurate identification of the underlying pathophysiology for BD is fundamental to realize major health benefits through better treatment and preventive regimens. However, to achieve these goals requires coordinated action and innovative approaches to boost the discovery of the neurobiological underpinnings of BD, and rapid translation of research findings into development and testing of better and more specific treatments. To this end, we here propose that only a large-scale coordinated action can be successful in integrating international big-data approaches with real-world clinical interventions. This could be achieved through the creation of a Global Bipolar Disorder Foundation, which could bring government, industry and philanthropy together in common cause. A global initiative for BD research would come at a highly opportune time given the seminal advances promised for our understanding of the genetic and brain basis of the disease and the obvious areas of unmet clinical need. Such an endeavour would embrace the principles of open science and see the strong involvement of user groups and integration of dissemination and public involvement with the research programs. We believe the time is right for a step change in our approach to understanding, treating and even preventing BD effectively. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/)