Evaluation of renal effects of liposomal amphotericin B in children with malignancies with KDIGO and RIFLE criteria
NEPHROLOGIE & THERAPEUTIQUE, cilt.17, sa.7, ss.507-511, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 7
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.nephro.2021.06.007
- Dergi Adı: NEPHROLOGIE & THERAPEUTIQUE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.507-511
- Anahtar Kelimeler: Liposomal amphotericin B, Children, Malignancies, KDIGO, RIFLE
- Dokuz Eylül Üniversitesi Adresli: Hayır
Özet
Background. - Amphotericin B is a broad-spectrum antifungal agent and is the backbone of the treatment for medically important opportunistic fungal pathogens in children. This study aimed to compare the nephrotoxicity associated with L-AmB in children with acute lymphoblastic leukemia and acute myeloid leukemia. Materials and methods. - A total of 112 pediatric acute lymphoblastic leukemia or acute myeloid leukemia patients who received treatment with L-AmB (Ambisome1) at the University of Health Sciences Dr Behcet Uz Children's Hospital over 7 years were included. The incidence of hypokalemia, decreased estimated glomerular filtration rate and presence of acute kidney injury was recorded. Results. - The average L-AmB treatment duration was 17.1 +/- 15.0 days. Five patients (4.4%) of the patients had grade I acute renal injury according to KDIGO criteria and 16 patients (14.2%) had increased risk for kidney injury according to RIFLE criteria. There were no patients with eGFR decrease above 50% and no renal injury and failure were observed during L-AmB treatment. The rate of patients with hypokalemia in the pretreatment was 17.9% and the post-L-AmB group was 50.0%. The rate of hypokalemia was higher in the posttreatment group (P = 0.0015). Among the 112 patients, only two patients (1.7%) required cessation of L-AmB treatment due to resistant hypokalemia despite supplementation. Conclusions. - Hypokalemia was more common compared to glomerulotoxicity and acute renal injury (according to KDIGO and RIFLE criteria) in pediatric leukemia patients treated with L-AmB. Hypokalemia developed in nearly half of the patients and the study shows the need for randomized controlled trials and strategies for hypokalemia associated with L-AmB treatment. (c) 2021 Socie acute accent te acute accent francophone de ne acute accent phrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.