Changes of thyroid hormonal status in patients receiving ketogenic diet due to intractable epilepsy

Kose E., Guzel O., DEMİR K., ARSLAN N.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.30, sa.4, ss.411-416, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1515/jpem-2016-0281
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.411-416
  • Anahtar Kelimeler: children, epilepsy, hypothyroidism, ketogenic diet, thyroid hormones, PROTEIN-CALORIE MALNUTRITION, SUBCLINICAL HYPOTHYROIDISM, FUNCTION TESTS, SERUM, THYROXINE, METABOLISM, TRIIODOTHYRONINE, THYROTROPIN, STARVATION, CHILDHOOD
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Ketogenic diet (KD), which is high in fat and low in carbohydrates, mimics the metabolic state of starvation and is used therapeutically for pharmacoresistant epilepsy. It is known that generation of triiodothyronine (T3) from thyroxine (T4) decreases during fasting periods. The aim of this study was to evaluate the thyroid function of children receiving KD for at least 1 year due to drug-resistant epilepsy.