In vitro antibacterial activities of erythromycin, clarithromycin, azithromycin and cephradine against methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains

Gulay Z., Yulug N.

Turkish Journal of Medical Sciences, cilt.22, sa.4, ss.229-231, 1994 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 1994
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.229-231
  • Anahtar Kelimeler: macrolide antibiotics, methicillin susceptibility, Staphylococcus aureus strains
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The in vitro antibacterial activities of erythromycin, clarithromycin, and azithromycin were evaluated against 75 methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains isolated from the hospital and outpatient clinics by the broth microdilution method and these activities were compared with those of cephradine. Of these strains, 35 (47%) were isolated from in-patients and 40 (53%) from out-patients. A total of 19 (54.3%) of the hospital and 16 (40%) of the outpatient-clinic isolates were resistant to methicillin as determined by the disc diffusion method. Of the methicillin-sensitive hospital isolates, 75% were also susceptible to erythromycin, clarithromycin, and azithromycin (MIC range 0.25-64 μg/ ml), and 68.7% were susceptible to cephradine. For the strains (methicillin-resistant and methicillin-sensitive) that were isolated from outpatient clinics, the overall sensitivity rates were not statistically different, although the MIC values were lower for all the agents tested when compared with hospital isolates.