The pathogenetic role of HLA-B27 and its subtypes

Khan M. A., Mathieu A., Sorrentino R., Akkoc N.

AUTOIMMUNITY REVIEWS, cilt.6, sa.3, ss.183-189, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.autrev.2006.11.003
  • Dergi Adı: AUTOIMMUNITY REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-189
  • Anahtar Kelimeler: animal models, ankylosing spondylitis, HLA-B27, pathogenesis, ANKYLOSING-SPONDYLITIS, INFLAMMATORY DISEASE, MOLECULAR MIMICRY, TRANSGENIC RATS, SELF-PEPTIDES, SUSCEPTIBILITY, ASSOCIATION, MECHANISM, ARTHRITIS, SARDINIA
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The strong association between HLA-B27 and ankylosing spondylitis has been known for more than 33 years, but the enigma of the pathogenetic role of the gene and its product has not yet been solved. Ongoing studies have produced evidence supporting different theories to explain this association, and structural and functional studies of HLA-B27 allele products at molecular level have provided information of broad and multidisciplinary value and disclosed new avenues leading to autoimmunity and immune disregulation. (c) 2006 Elsevier B.V. All rights reserved.