The pathogenetic role of HLA-B27 and its subtypes


Khan M. A., Mathieu A., Sorrentino R., Akkoc N.

AUTOIMMUNITY REVIEWS, vol.6, no.3, pp.183-189, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.autrev.2006.11.003
  • Journal Name: AUTOIMMUNITY REVIEWS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.183-189
  • Keywords: animal models, ankylosing spondylitis, HLA-B27, pathogenesis, ANKYLOSING-SPONDYLITIS, INFLAMMATORY DISEASE, MOLECULAR MIMICRY, TRANSGENIC RATS, SELF-PEPTIDES, SUSCEPTIBILITY, ASSOCIATION, MECHANISM, ARTHRITIS, SARDINIA
  • Dokuz Eylül University Affiliated: No

Abstract

The strong association between HLA-B27 and ankylosing spondylitis has been known for more than 33 years, but the enigma of the pathogenetic role of the gene and its product has not yet been solved. Ongoing studies have produced evidence supporting different theories to explain this association, and structural and functional studies of HLA-B27 allele products at molecular level have provided information of broad and multidisciplinary value and disclosed new avenues leading to autoimmunity and immune disregulation. (c) 2006 Elsevier B.V. All rights reserved.