P21 and p27 Immunoexpression in Upper Urinary Tract Urothelial Carcinomas

SARSIK KUMBARACI B., Doganavsargil B., ŞİMŞİR A., Yazici A., Pehlivanoglu B., Cal C., ...Daha Fazla

PATHOLOGY & ONCOLOGY RESEARCH, cilt.22, sa.4, ss.839-845, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s12253-016-0075-4
  • Dergi Adı: PATHOLOGY & ONCOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.839-845
  • Anahtar Kelimeler: Cylin-dependent kinase inhibitors, p21, p27, Prognosis, Upper tract urothelial carcinoma, Urinary tract, DEPENDENT KINASE INHIBITOR, TRANSITIONAL-CELL CARCINOMA, INVASIVE BLADDER-CANCER, PROGNOSTIC-SIGNIFICANCE, RADICAL NEPHROURETERECTOMY, KI-67 EXPRESSION, RENAL PELVIS, RISK-FACTORS, P27(KIP1), P53
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

p21 and p27 are members of cyclin-dependent kinase family, which function as tumor suppressors and they are involved in development and progression of several malignancies. We investigated their expression in upper urinary tract urothelial carcinoma (UUTUC). Radical nephroureterectomy materials of 34 patients were assessed by immunohistochemistry to evaluate expression of p21 and p27 in UUTUC. Results were correlated with various clinicopathological variables as age, gender, tumor grade and stage, tumor architecture, multifocality, subsequent bladder carcinoma development and clinical outcome.