P21 and p27 Immunoexpression in Upper Urinary Tract Urothelial Carcinomas

SARSIK KUMBARACI B., Doganavsargil B., ŞİMŞİR A., Yazici A., Pehlivanoglu B., Cal C., ...More

PATHOLOGY & ONCOLOGY RESEARCH, vol.22, no.4, pp.839-845, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1007/s12253-016-0075-4
  • Journal Name: PATHOLOGY & ONCOLOGY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.839-845
  • Keywords: Cylin-dependent kinase inhibitors, p21, p27, Prognosis, Upper tract urothelial carcinoma, Urinary tract, DEPENDENT KINASE INHIBITOR, TRANSITIONAL-CELL CARCINOMA, INVASIVE BLADDER-CANCER, PROGNOSTIC-SIGNIFICANCE, RADICAL NEPHROURETERECTOMY, KI-67 EXPRESSION, RENAL PELVIS, RISK-FACTORS, P27(KIP1), P53
  • Dokuz Eylül University Affiliated: No

Abstract

p21 and p27 are members of cyclin-dependent kinase family, which function as tumor suppressors and they are involved in development and progression of several malignancies. We investigated their expression in upper urinary tract urothelial carcinoma (UUTUC). Radical nephroureterectomy materials of 34 patients were assessed by immunohistochemistry to evaluate expression of p21 and p27 in UUTUC. Results were correlated with various clinicopathological variables as age, gender, tumor grade and stage, tumor architecture, multifocality, subsequent bladder carcinoma development and clinical outcome.