Polysomy 8 Syndrome: A Distinct Clinical Entity Comprising of Myelomonocytic/Monocytic Lineage Involvement in Acute Leukemia

YÜCE Z., Yuksel E., PEHLİVAN M., Sevindik O. G., ALACACIOĞLU İ., ALTUNGÖZ O.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.3, sa.2, ss.42-45, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.30621/jbachs.2019.505
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.42-45
  • Anahtar Kelimeler: Tetrasorny 8, Acute Myeloid Leukemia, AML-M5, Myeloid Sarcoma, Polysomy 8 Syndrome, Cytogenetics, PROLIFERATIVE ADVANTAGE, CHROMOSOMAL-ABNORMALITY, CLONAL EVOLUTION, POOR-PROGNOSIS, TETRASOMY, TRANSLOCATION, TRISOMY-8, PATIENT, CHILD
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Cytogenetic abnormalities have been proven to be among the most valuable prognostic indicators in leukemia, allowing the stratification of patients in risk groups. We describe a patient diagnosed as AML-M5, with myeloid sarcoma and tetrasomy 8 as the sole chromosomal abnormality. We confirm that the presence of polysomy 8 in myeloid lineage malignancies is associated with a distinct clinical entity comprising of myelornonocytic/monocytic lineage involvement, poor prognosis and high incidence of myeloid sarcoma. In aim to obtain a detailed description of this clinical entity, literature of polysomy 8 cases has been reviewed.