Renal cell carcinoma associated immunosuppressive therapy: a case report with Wegener's granulomatosis

DEĞER S. M., Mutluay R., Ebinc F. A., Arinsoy T., Sindel S.

RHEUMATOLOGY INTERNATIONAL, vol.30, no.1, pp.119-121, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1007/s00296-009-0911-x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-121
  • Keywords: Wegener's granulomatosis (WG), Renal cell carcinoma (RCC), Cyclophosphamide, Azathioprine, Vasculitis, CYCLOPHOSPHAMIDE, MALIGNANCIES, TRIAL
  • Dokuz Eylül University Affiliated: No


Development of uroepithelial tumors after cyclophosphamide and azathioprine therapy in Wegener's granulomatosis (WG) have been reported in the literature but renal cell carcinoma (RCC), rarely. RCC associated with WG has been previously reported in a few cases. Most of them have simultaneous diseases. Here, we report a case, which developed RCC 8 years after initiation of WG. Long-term immunosuppressive treatment is a risk factor for the development of malignancies; it should be suggested that RCC in our patient might be due to immunosuppressive therapy.