Protective effect of melatonin against maternal deprivation-induced acute hippocampal damage in infant rats
NEUROSCIENCE LETTERS, cilt.398, sa.1-2, ss.145-150, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 398 Sayı: 1-2
- Basım Tarihi: 2006
- Doi Numarası: 10.1016/j.neulet.2005.12.090
- Dergi Adı: NEUROSCIENCE LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.145-150
- Anahtar Kelimeler: maternal deprivation, infant rat, hippocampal neuron death, melatonin
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
It is known that maternal deprivation induces hippocampal damage in the developing brains. In the present study, we examined the effects of melatonin on maternal deprivation-induced hippocampal damage both during and after stress-hyporesponsive period (SHRP). Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. The results showed that a single episode of maternal deprivation for 24 It at post-SHRP induced neuronal loss in hippocampus regions of the brain in the infant rats, while it did not influence hippocampal neurons in SHRP. Melatonin prevented maternal deprivation-induced hippocampal damage in the infant rats at post-SHRP. These results suggest that melatonin is a potentially beneficial agent to improve the neurobehavioral outcomes of maternal deprivation in later developmental period. (C) 2006 Elsevier Ireland Ltd. All rights reserved.