Protective effect of melatonin against maternal deprivation-induced acute hippocampal damage in infant rats

Tugyan K., Uysal Harzadın N., Ozdemir D., Sonmez Ü., Pekcetin Ç., Erbil G., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.398, sa.1-2, ss.145-150, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 398 Sayı: 1-2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.neulet.2005.12.090
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.145-150
  • Anahtar Kelimeler: maternal deprivation, infant rat, hippocampal neuron death, melatonin, OXIDATIVE STRESS, CELL-PROLIFERATION, NERVOUS-SYSTEM, DENTATE GYRUS, PITUITARY, SEPARATION, REDUCTION, RESPONSES, ANXIETY, MEMORY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

It is known that maternal deprivation induces hippocampal damage in the developing brains. In the present study, we examined the effects of melatonin on maternal deprivation-induced hippocampal damage both during and after stress-hyporesponsive period (SHRP). Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. The results showed that a single episode of maternal deprivation for 24 It at post-SHRP induced neuronal loss in hippocampus regions of the brain in the infant rats, while it did not influence hippocampal neurons in SHRP. Melatonin prevented maternal deprivation-induced hippocampal damage in the infant rats at post-SHRP. These results suggest that melatonin is a potentially beneficial agent to improve the neurobehavioral outcomes of maternal deprivation in later developmental period. (C) 2006 Elsevier Ireland Ltd. All rights reserved.