Lighting up <i>Mycobacteria</i> with membrane-targeting peptides

Alghamdi Z. S., Sharma R., Kiruthiga N., ÜÇÜNCÜ M., Klausen M., Santra M., ...Daha Fazla

ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.22, sa.44, ss.8781-8786, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 44
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1039/d4ob01333f
  • Dergi Adı: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.8781-8786
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

We report a series of fluorescent probes based on mycobacteria membrane-associated disruption peptide, containing either L- or D-amino acids which were originally designed to kill Mycobacterium tuberculosis via membrane disruption. These peptides were decorated with "always on" and environmentally sensitive fluorophores and showed the rapid and efficient labelling of Mycobacterium smegmatis, with labelling of Mycobacterium tuberculosis demonstrated by two of the probes.