Lighting up <i>Mycobacteria</i> with membrane-targeting peptides

Alghamdi Z. S., Sharma R., Kiruthiga N., ÜÇÜNCÜ M., Klausen M., Santra M., ...More

ORGANIC & BIOMOLECULAR CHEMISTRY, vol.22, no.44, pp.8781-8786, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 44
  • Publication Date: 2024
  • Doi Number: 10.1039/d4ob01333f
  • Journal Name: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.8781-8786
  • Dokuz Eylül University Affiliated: No

Abstract

We report a series of fluorescent probes based on mycobacteria membrane-associated disruption peptide, containing either L- or D-amino acids which were originally designed to kill Mycobacterium tuberculosis via membrane disruption. These peptides were decorated with "always on" and environmentally sensitive fluorophores and showed the rapid and efficient labelling of Mycobacterium smegmatis, with labelling of Mycobacterium tuberculosis demonstrated by two of the probes.