Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism

Kebapcilar L., ÇÖMLEKÇİ A., Tuncel P., Solak A., SEÇİL M., Gencel O., ...More

MEDICAL SCIENCE MONITOR, vol.16, no.1, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2010
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: paraoxonase-1, carotid intima-media thickness, subclinical hypothyroidism, C-REACTIVE PROTEIN, HIGH-DENSITY-LIPOPROTEIN, CORONARY-HEART-DISEASE, RISK-FACTORS, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, FOLLOW-UP, INDEPENDENT PREDICTOR, LIPID PROFILE, ATHEROSCLEROSIS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Paraoxonase-1 (PON-1) may play an important role in atherosclerosis. Atherosclerosis is an inflammatory disease and C-reactive protein is a marker for inflammation. The aim of this study was to determine serum PON-1 activity and high-sensitivity C-reactive protein (hs-CRP) levels and assess carotid intima-media thickness, a marker of early atherosclerotic changes, in patients with subclinical hypothyroidism.