Convergence spasm due to aquaporin-positive neuromyelitis optica spectrum disorder

Özçelik P., Tanriverdizade T., MEN S., Akdal G.

eNeurologicalSci, vol.7, pp.7-8, 2017 (Scopus) identifier identifier

  • Publication Type: Article / Letter
  • Volume: 7
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ensci.2017.03.001
  • Journal Name: eNeurologicalSci
  • Journal Indexes: Scopus
  • Page Numbers: pp.7-8
  • Keywords: Aquaporin 4 antibody, Convergence spasm, Neuromyelitis optica
  • Dokuz Eylül University Affiliated: Yes


© 2017 The Author(s)A female 27 presented with nausea and diplopia for 1 week. On examination she had normal vertical gaze but would develop convergence with miosis whenever she made horizontal saccades. Pupils were 6 mm and unreactive to light. MRI showed extensive hyperintensity in the dorsal midbrain and thalamus. Spinal MRI and CSF were both normal. Serum aquaporin-4-antibody was positive. She was treated with steroids and plasmapheresis and after 3 months convergence spasm resolved but pupils remained unreactive. Neuromyelitis optica often presents with brainstem signs, rarely a dorsal midbrain syndrome. Convergence spasm is occasionally of organic neurologic origin.