Effect of galantamine on platelet functions in healthy elderly people


IŞIK A. T., Bozoglu E., Kaptan K., Celik T.

INDIAN JOURNAL OF MEDICAL RESEARCH, vol.137, pp.977-980, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137
  • Publication Date: 2013
  • Journal Name: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.977-980
  • Keywords: Alzheimer disease, elderly, galantamine, platelets, PROBABLE VASCULAR DEMENTIA, PLACEBO-CONTROLLED TRIAL, ALZHEIMERS-DISEASE, CARDIOVASCULAR EVENTS, PREVENTION, SAFETY, DRUG
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background & objectives: Galantamine, a centrally-acting cholinesterase inhibitor, has been used in the treatment of mild-to-moderate dementia of Alzheimer disease. Increased mortality, mainly due to cardiovascular events, was observed in placebo-controlled trials of galantamine. Several studies have evaluated the efficacy of galantamine in dementia, it is not clear whether it has an effect on platelet function. It is important to clarify this effect, because it may be related to thrombotic tendency or bleeding diathesis. This study was aimed to investigate the effect of galantamine on platelet aggregation in whole blood from healthy, elderly subjects.