Effect of galantamine on platelet functions in healthy elderly people

IŞIK A. T., Bozoglu E., Kaptan K., Celik T.

INDIAN JOURNAL OF MEDICAL RESEARCH, cilt.137, ss.977-980, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137
  • Basım Tarihi: 2013
  • Dergi Adı: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.977-980
  • Anahtar Kelimeler: Alzheimer disease, elderly, galantamine, platelets, PROBABLE VASCULAR DEMENTIA, PLACEBO-CONTROLLED TRIAL, ALZHEIMERS-DISEASE, CARDIOVASCULAR EVENTS, PREVENTION, SAFETY, DRUG
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background & objectives: Galantamine, a centrally-acting cholinesterase inhibitor, has been used in the treatment of mild-to-moderate dementia of Alzheimer disease. Increased mortality, mainly due to cardiovascular events, was observed in placebo-controlled trials of galantamine. Several studies have evaluated the efficacy of galantamine in dementia, it is not clear whether it has an effect on platelet function. It is important to clarify this effect, because it may be related to thrombotic tendency or bleeding diathesis. This study was aimed to investigate the effect of galantamine on platelet aggregation in whole blood from healthy, elderly subjects.