Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch-Anal Anastomosis

ATİLA K., Terzi C., Canda A. E., Akhisaroglu S. T., Avci H. S., SARIOĞLU S., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.54, no.3, pp.522-529, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1007/s10620-008-0377-9
  • Journal Name: DIGESTIVE DISEASES AND SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.522-529
  • Keywords: Dextran sulfate sodium, Dietary fiber, Guar gum, Short chain fatty acid, Pouchitis, INFLAMMATORY-BOWEL-DISEASE, DISTAL ULCERATIVE-COLITIS, PLACEBO-CONTROLLED TRIAL, SULFATE-INDUCED COLITIS, SODIUM-INDUCED COLITIS, CHAIN FATTY-ACIDS, MONOCLONAL-ANTIBODY, RECTAL IRRIGATION, ENEMAS, COLON
  • Dokuz Eylül University Affiliated: Yes

Abstract

We aimed to evaluate the efficacy of treatment with partially hydrolyzed guar gum (PHGG) using a rat model of ileal pouch-anal anastomosis and pouchitis. In the J pouch groups, tissue myeloperoxidase activities were significantly higher than native myeloperoxidase activities (P = 0.020; P = 0.015; P = 0.004, respectively). A statistically significant difference in total histological score was detected in the J pouch + 5% dextran sulfate sodium (DSS) group, compared to the J pouch control and the J pouch + 5% DSS + PHGG groups (P < 0.01 and P < 0.01, respectively). There was a significant overgrowth of aerobes and anaerobes in the J pouch + 5% DSS group. This study demonstrated that rectal administration of PHGG attenuates the severity of pouchitis in a rat model. In conclusion, PHGG may be an additional therapeutic strategy for the treatment of pouchitis.