Antithrombin III pretreatment reduces neutrophil recruitment into the lung in a rat model of abdominal sepsis.

Koca U., Olguner Ç. G., Ozkardesler S., Karci A., Coker C., Tuncel P., ...More

Acta anaesthesiologica Scandinavica, vol.49, no.2, pp.203-8, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1399-6576.2004.00567.x
  • Journal Name: Acta anaesthesiologica Scandinavica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.203-8
  • Keywords: antithrombin, sepsis, anti-inflammatory, prostacyclin, activated leukocytes, heparin-like glycosaminoglycans, ANIMAL-MODELS, SEPTIC SHOCK, CECAL LIGATION, INJURY, PROSTACYCLIN, INFLAMMATION, COAGULATION, PROTECTION, PREVENTS, EFFICACY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Antithrombin III (AT III) is a serine protease inhibitor and the mechanism of its anti-inflammatory action is still not understood. In the present study, we aimed to investigate the anti-inflammatory action of AT III on lung injury in a rat model of sepsis.