Adoptive T-cell therapy of cancer


Erbayraktar Z.

JOURNAL OF BUON, vol.14, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2009
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: adoptive immunotherapy, cancer, T cell, TUMOR-INFILTRATING LYMPHOCYTES, EPSTEIN-BARR-VIRUS, COLONY-STIMULATING FACTOR, PERIPHERAL-BLOOD LYMPHOCYTES, INTERFERON-GAMMA SECRETION, VACCINE-PRIMED LYMPHOCYTES, HIGH-DOSE INTERLEUKIN-2, ALLOGENEIC BONE-MARROW, LYMPH-NODE LYMPHOCYTES, ACTIVATED KILLER-CELLS
  • Dokuz Eylül University Affiliated: No

Abstract

Adoptive immunotherapy is determined as "the isolation of antigen-specific cells, their ex vivo expansion and activation, and subsequent autologous administration" and is a promising approach to inducing antitumour immune responses. Identification of tumour antigens and monitoring the persistence and transport of transferred cells has provided our understanding over the mechanisms of tumour immunotherapy. Cell-transfer therapies have seems beneficial for the treatment of patients with selected metastatic cancers by providing a blueprint for the wider application of adoptive cell transfer (ACT) therapy, and emphasize the requirement for in vivo persistence of the cells for therapeutic efficacy.