The Importance of Fecal and Plasma CEA, COX-2, MMP-7, and TIMP-1 in the Diagnosis of Colorectal Cancer


Kiyak R., Keles D., BENGİ G., Yalcin M., Topalak O., OKTAY G.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.2, no.1, pp.7-14, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.30621/jbachs.2018.259
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.7-14
  • Keywords: Colorectal cancer, colorectal polyps, tissue inhibitors of metalloproteinases-1, matrix metalloproteinase-7, cyclooxygenase-2, carcinoembryonic antigen, CARCINOEMBRYONIC ANTIGEN, TISSUE INHIBITOR, OCCULT BLOOD, MATRIX METALLOPROTEINASES, MATRILYSIN EXPRESSION, POOR-PROGNOSIS, CARCINOMA, ADENOMAS, SURVIVAL, MATRIX-METALLOPROTEINASE-7
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Colorectal cancer (CRC) is one of the most common and death related cancers in the world. Therefore, the early diagnosis of CRC remains with a great importance to prevent its further progression and increase survival rates. Colonoscopy and pathological examinations which are invasive and painful procedures, are needed to make a definitive diagnosis of CRC. The carcinoembryonic antigen (CEA) is particularly used for postoperative follow-up of CRC patients. The imbalance between matrix metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs) leads to degradation of extracellular matrix which is the most important step in invasion and metastasis. It was also observed that cyclooxygenase-2 (COX-2) has crucial roles in the development and progression of colorectal cancer. The purpose of our study is to detect fecal and plasma MMP-7, COX-2, TIMP-1, and CEA protein levels in patients with colorectal cancer, colorectal polyps, and healthy individuals, and assess their association with each other and with clinicopathological variables. We also aimed to evaluate plasma and fecal MMP-7, COX-2, TIMP-1, and CEA protein levels as potential diagnostic markers in colorectal carcinoma.