The Serum Prolidase Enzyme Activity as a Biomarker for Evaluation of the Subclinical Vascular Damage n Children with Epilepsy


Karacan N., Calik M., Kazanasmaz H., Ethemoglu O., Guzelcicek A., Yasin S., ...More

ANNALS OF INDIAN ACADEMY OF NEUROLOGY, vol.23, no.6, pp.787-791, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.4103/aian.aian_640_19
  • Journal Name: ANNALS OF INDIAN ACADEMY OF NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.787-791
  • Keywords: Biomarkers, children, epilepsy, oxidative stress, serum prolidase enzyme activity, vascular damage, INTIMA-MEDIA THICKNESS, OXIDATIVE STRESS, RISK-FACTORS, ANTIEPILEPTIC DRUGS, VALPROIC ACID, PREVALENCE, CARBAMAZEPINE, MONOTHERAPY, ATHEROSCLEROSIS, DISTURBANCES
  • Dokuz Eylül University Affiliated: Yes

Abstract

Backgroud: Epilepsy is a chronic medical condition requiring long term or even lifelong therapy. Various researches have shown that epilepsy patients have vascular risk factors such as abnormal lipids, insulin, elevated oxidative stress, chronic inflammation, and subclinical atherosclerosis. Objectives: The purpose of the present study was to determine serum prolidase enzyme activity as a biomarker in children taking antiepileptic drug treatment through comparison with control cases. Materials and Methods: The present study group consists of 61 children (20 females, 41 males) with epilepsy and a control group was formed of 32 healthy individuals (14 females, 18 males). Aspectrophotometric method was used to measure serum prol idase enzyme activity. Results: The epilepsy group demonstrated statistically significantly higher prolidase enzyme activity values when compared with the control group (P = 0.003). It was measured that the serum TOS and OSI values were significantly elevated in patients with epilepsy compared to controls (P < 0.001). However, serum TAS values were significantly lower in the epilepsy group than in the control group (P = 0.032). Conclusions: These results supported that epileptic patients taking the antiepileptic treatment had increased serum prolidase enzyme activity, suggesting that it may show an increased risk of subclinical vascular damage related to both chronic inflammation and fibrotic process associated with degenerated collagen turnover. Therefore, serum prolidase enzyme activity could be considered a useful biomarker for evaluation of the subclinical vascular damage in children with epilepsy on some antiepileptic drugs.