Anemia in Patients With Resistance to Thyroid Hormone alpha: A Role for Thyroid Hormone Receptor a in Human Erythropoiesis

van Gucht A. L. M., Meima M. E., Moran C., Agostini M., Tylki-Szymanska A., Krajewska-Walasek M., ...Daha Fazla

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.102, sa.9, ss.3517-3525, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 102 Sayı: 9
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1210/jc.2017-00840
  • Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3517-3525
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Context: Patients with resistance to thyroid hormone (TH) alpha (RTH alpha) are characterized by growth retardation, macrocephaly, constipation, and abnormal thyroid function tests. In addition, almost all RTH alpha patients have mild anemia, the pathogenesis of which is unknown. Animal studies suggest an important role for TH and TH receptor (TR)alpha in erythropoiesis.