Anemia in Patients With Resistance to Thyroid Hormone alpha: A Role for Thyroid Hormone Receptor a in Human Erythropoiesis

---

Copy For Citation

van Gucht A. L. M., Meima M. E., Moran C., Agostini M., Tylki-Szymanska A., Krajewska-Walasek M., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.102, no.9, pp.3517-3525, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 102 Issue: 9
• Publication Date: 2017
• Doi Number: 10.1210/jc.2017-00840
• Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.3517-3525
• Dokuz Eylül University Affiliated: Yes

Abstract

Context: Patients with resistance to thyroid hormone (TH) alpha (RTH alpha) are characterized by growth retardation, macrocephaly, constipation, and abnormal thyroid function tests. In addition, almost all RTH alpha patients have mild anemia, the pathogenesis of which is unknown. Animal studies suggest an important role for TH and TH receptor (TR)alpha in erythropoiesis.