Propofol infusion syndrome or adrenoleukodystrophy?

Karaman Y., Goktay A., Agin H., Karaarslan U.

PEDIATRIC ANESTHESIA, vol.23, no.4, pp.368-370, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.1111/pan.12113
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.368-370
  • Keywords: propofol, propofol infusion syndrome, adrenoleukodystrophy, ANESTHESIA
  • Dokuz Eylül University Affiliated: No


Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis. A presumed diagnosis of propofol infusion syndrome (PRIS) was made, but further investigation revealed neonatal adrenoleukodystrophy. PRIS should be considered with this constellation of symptoms, but other neurometabolic disorders must always be ruled out.