Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat

Canpolat S., SANDAL S., YILMAZ B., Yasar A., Kutlu S., Baydas G., ...More

European Journal of Pharmacology, vol.428, no.1, pp.145-148, 2001 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 428 Issue: 1
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-2999(01)01230-4
  • Journal Name: European Journal of Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-148
  • Keywords: leptin, melatonin, pinealectomy, (rat)
  • Dokuz Eylül University Affiliated: Yes

Abstract

The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine) on serum leptin levels were investigated in rats. Exogenous administration of melatonin to intact rats resulted in significant decreases in serum leptin levels (P < 0.05) compared to those of the intact control group. Serum leptin levels were significantly elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals (P < 0.001) and were significantly suppressed by exogenous administration of melatonin compared to those of non-treated pinealectomised rats (P < 0.001). Hormone concentrations in the melatonin-treated pinealectomised group were found to be similar to those seen in the sham-pinealectomised group. These results suggest that pineal gland has an effect on leptin release. © 2001 Elsevier Science B.V. All rights reserved.