Beyond biomarkers: Identifying cell state using unbiased nanosensor arrays

Duncan B., ELÇİ Ş. G., Rotello V. M.

NANO TODAY, cilt.7, sa.4, ss.228-230, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 7 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.nantod.2012.06.001
  • Dergi Adı: NANO TODAY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.228-230
  • Anahtar Kelimeler: Unbiased sensors, Biomarkers, Cancer cells, Nanoparticles
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Traditional cell detection based on biomarkers relies on specific lock-and-key recognition. However, many diseases either do not have obvious biomarkers or these markers are currently unknown. Unbiased sensor arrays based on nanoparticles use selective interactions to generate bioprofiles capable of identifying cell type and state. As a result, these arrays can differentiate subtle variations on the cell surfaces, presenting a potential approach for personalized diagnostics. (c) 2012 Elsevier Ltd. All rights reserved.