The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses


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Sag D., Ayyildiz Z. O., Gunalp S., Wingender G.

CANCERS, vol.11, no.10, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 11 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.3390/cancers11101469
  • Journal Name: CANCERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: apoptosis, immune regulation, tumor, myeloid cells, lymphoid cells, APOPTOSIS-INDUCING LIGAND, NATURAL-KILLER-CELLS, CD8(+) T-CELLS, PLASMACYTOID DENDRITIC CELLS, INNATE LYMPHOID-CELLS, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, UNFOLDED PROTEIN RESPONSE, CHRONIC HEPATITIS-C, HUMAN MAST-CELLS, HUMAN B-CELLS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular.