Delayed Renal Excretion of Methotrexate After a Severe Anaphylactic Reaction to Methotrexate in a Child With Osteosarcoma

Ozguven A. A., Uysal K., Gunes D., Koroglu T., Gurcu O., Olgun N.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.31, sa.4, ss.289-291, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1097/mph.0b013e318199388c
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.289-291
  • Anahtar Kelimeler: anaphylactic reaction, methotrexate, delayed excretion, HIGH-DOSE METHOTREXATE, HYPERSENSITIVITY REACTIONS, SYSTEMIC-ANAPHYLAXIS, CHEMOTHERAPY, ETOPOSIDE, THERAPY, PATIENT, SARCOMA
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Although methotrexate is an agent widely used in the practice of pediatric oncology, allergic reactions to methotrexate are most unusual. Most of these reactions typically occur after repeated administration. Here, we report it severe anaphylactoid reaction to the first close of high-dose methotrexate infusion in a child with osteosarcoma who has also experienced it delayed excretion of methotrexate. Clinicians must be aware of the possibility of a systemic, near-fatal anaphylactic reactions with methotrexate and patients who experience severe anaphylactic reactions should be followed carefully because of the possibility of delayed methotrexate excretion.