Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population

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Kornilov S. A., Rakhlin N., Koposov R., Lee M., Yrigollen C., ÇAĞLAYAN A. O., ...Daha Fazla

PEDIATRICS, cilt.137, sa.4, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1542/peds.2015-2469
  • Dergi Adı: PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

BACKGROUND AND OBJECTIVE: Developmental language disorder (DLD) is a highly prevalent neurodevelopmental disorder associated with negative outcomes in different domains; the etiology of DLD is unknown. To investigate the genetic underpinnings of DLD, we performed genome-wide association and whole exome sequencing studies in a geographically isolated population with a substantially elevated prevalence of the disorder (ie, the AZ sample).