Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population

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Kornilov S. A., Rakhlin N., Koposov R., Lee M., Yrigollen C., ÇAĞLAYAN A. O., ...More

PEDIATRICS, vol.137, no.4, 2016 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 137 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1542/peds.2015-2469
  • Journal Name: PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: No

Abstract

BACKGROUND AND OBJECTIVE: Developmental language disorder (DLD) is a highly prevalent neurodevelopmental disorder associated with negative outcomes in different domains; the etiology of DLD is unknown. To investigate the genetic underpinnings of DLD, we performed genome-wide association and whole exome sequencing studies in a geographically isolated population with a substantially elevated prevalence of the disorder (ie, the AZ sample).