Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women
Clinical and Experimental Hypertension, vol.38, no.2, pp.189-193, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 38 Issue: 2
- Publication Date: 2016
- Doi Number: 10.3109/10641963.2015.1081215
- Journal Name: Clinical and Experimental Hypertension
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.189-193
- Keywords: 5-HT, placenta, 5-HT7 receptor, pre-eclampsia
- Dokuz Eylül University Affiliated: Yes
Abstract
In this study, by examining 5-HT7 receptor expression in placentae from pre-eclamptic and normal pregnancies, we aimed to discover a new step of pathophysiological cascade for preeclampsia. Patients whose blood pressure over the 140/90 mmHg were included when study after 20 weeks of gestation. 5-HT7 receptor expression was investigated on the placentae obtained after birth by real time PCR (RT-PCR) analysis. Pre-natal-post-natal, systolic-diastolic blood pressure values, proteinuria and renal function indicators as BUN and creatinine levels of pre-eclamptic pregnant women were higher than the healthy group. Similarly, 5-HT7 receptor expression determined in healthy placentae increased 8-fold in pre-eclamptic women. This study, for the first time we showed 5-HT7 receptor expression in normal placenta and increased expression in pre-eclamptic placenta.