Papular Lesions on the Forearms in a 56-Year-Old Woman

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Öner S., Avcı C., Lebe B.

JAAD CASE REPORTS, cilt.66, sa.December 2025, ss.1-3, 2025 (Scopus)

  • Yayın Türü: Makale / Vaka Takdimi
  • Cilt numarası: 66 Sayı: December 2025
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.jdcr.2025.08.037
  • Dergi Adı: JAAD CASE REPORTS
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, Directory of Open Access Journals, PubMed
  • Sayfa Sayıları: ss.1-3
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

CASE DESCRIPTION

A 56-year-old woman presented with a 4-y history of persistent, asymptomatic papules symmetrically located

on the dorsum of her hands and distal forearms (Fig 1). There was no history of trauma, systemic illness, or

medication use. Her personal and family history were noncontributory. Dermatologic examination revealed

numerous 2-5 mm, firm, dome-shaped, flesh-colored papules without inflammation or secondary changes (Figs

2 and 3). A punch biopsy demonstrated orthokeratotic epidermis with prominent mucinous degeneration in the

superficial dermis separating collagen bundles without fibroblast proliferation (Fig 4). Histochemical staining

with Alcian blue was positive for mucin. Special stains, including Congo red, crystal violet, PAS, and elastic tissue

stain, were negative for amyloid, fungi, and elastic fiber alterations.

Question: Which of the following is the most likely diagnosis?

A. Papular granuloma annulare

B. Discrete papular lichen myxoedematosus

C. Acral persistent papular mucinosis

D. Eruptive xanthomas

E. Papular sarcoidosis