A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

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Atıf İçin Kopyala

Lopez A., Lee S. E., Wojta K., Ramos E. M., Klein E., Chen J., ...Daha Fazla

BRAIN, cilt.140, ss.1128-1146, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 140
• Basım Tarihi: 2017
• Doi Numarası: 10.1093/brain/awx005
• Dergi Adı: BRAIN
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1128-1146
• Anahtar Kelimeler: neurodegeneration, tauopathy, autophagy, proteasome, FAMILIAL PRESENILE-DEMENTIA, ALZHEIMERS-DISEASE, NEUROFIBRILLARY TANGLES, POLYGLUTAMINE EXPANSIONS, FRONTOTEMPORAL DEMENTIA, FLUORESCENT PROTEINS, HUNTINGTONS-DISEASE, SPECTRUM DISORDERS, P.A152T VARIANT, SENILE PLAQUES
• Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Mutations in the gene encoding tau ( MAPT) cause frontotemporal dementia spectrum disorders. A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia spectrum and Alzheimer's disease in an initial case-control study. Such findings need replication in an independent cohort. We analysed an independent multinational cohort comprising 3100 patients with neurodegenerative disease and 4351 healthy control subjects and found p. A152T associated with significantly higher risk for clinically defined frontotemporal dementia and progressive supranuclear palsy syndrome. To assess the functional and biochemical consequences of this variant, we generated transgenic zebrafish models expressing wild-type or A152T-tau, where A152T caused neurodegeneration and proteasome compromise. Impaired proteasome activity may also enhance accumulation of other proteins associated with this variant. We increased A152T clearance kinetics by both pharmacological and genetic upregulation of autophagy and ameliorated the disease pathology observed in A152T-tau fish. Thus, autophagy-upregulating therapies may be a strategy for the treatment for tauopathies.