Parathyroid Allotransplant for Persistent Hypocalcaemia: A New Technique Involving Short-Term Culture
EXPERIMENTAL AND CLINICAL TRANSPLANTATION, cilt.14, sa.2, ss.238-241, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2016
- Doi Numarası: 10.6002/ect.2014.0110
- Dergi Adı: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.238-241
- Dokuz Eylül Üniversitesi Adresli: Hayır
Özet
Objectives: To develop a new parathyroid allotransplant method for the treatment of permanent hypo parathyroidism. Materials and Methods: Parathyroid cells 50 x 10(6) derived from a parathyroid hyperplasia patient were transferred to a 61-year-old patient who had thyroidectomy 17 years earlier, allowing to papillary thyroid cancer; he was admitted to our outpatient clinic with symptomatic chronic hypocalcemia. Cell isolation, cryopreservation, and culturing were conducted according to a new protocol. Results: During a follow-up of 5 months, the patient had no complications that could indicate rejection, and clinical symptoms completely resolved without requiring any drug supplementation. Conclusions: Here, we report a new method, enabling fast and cost-effective parathyroid allotransplant with maintained tissue viability sufficient to treat persistent hypocalcemia.