Visual evoked potential is superior to triple dose magnetic resonance imaging in the diagnosis of optic nerve involvement
INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.114, sa.8, ss.1025-1033, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 114 Sayı: 8
- Basım Tarihi: 2004
- Doi Numarası: 10.1080/00207450490461332
- Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1025-1033
- Anahtar Kelimeler: magnetic resonance imaging, multiple sclerosis, optic neuritis, visual evoked potential
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
The aim of this study was to evaluate whether VEP is sensitive to optic neuritis (ON) when compared with triple dose orbital MRL Twenty-four relapsing-remitting MS (RRMS) patients were included in the study. Group I (n = 10) patients with acute ON, Group H (n = 8): patients presenting with a current relapse who had the history of ON in the previous relapses. Group III (n = 6): patients presenting with a current relapse but with no history of ON. Neuro-ophtalmological evaluation. VEP investigation and orbital MRI with triple dose (0.3 mmol/kg) gadolinium (Gd) were carried out for all. VEP was found to be 70% sensitive and 12.5% specific to the acute ON, whereas orbital MRI with triple dose Gd was 70% sensitive and 100% specific. In chronic ON, the sensitivity of orbital MRI is 0%, whereas the VEP is still 75% sensitive to chronic optic nerve involvement and can distinguish the pathology 100% specifically. In conclusion, orbital MRI with triple dose Gd is not more sensitive than VEP in determining the acute optic nerve pathologies but it is a 100% specific method The results suggest that VEP is superior to the orbital MRI in determining the chronic optic nerve involvement.