MEFV gene is a probable susceptibility gene for Behcet's disease

Imirzalioglu N., Dursun A., Tastan B., Soysal Y., Yakicier M.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, vol.34, no.1, pp.56-58, 2005 (SCI-Expanded) identifier identifier


Objective: Behcet's disease ( BD) is a rare, chronic, multisystem inflammatory disorder. The prevalence of BD is higher in the Middle Eastern and Mediterranean populations. Another chronic inflammatory disease, familial Mediterranean fever (FMF), is also known to be highly prevalent in these populations. The prevalence of BD is higher in the FMF patient population than in populations known to be rich in BD. Both BD and FMF have some pathophysiological features in common and they result from inappropriate activation of neutrophils. Clinical manifestations of both diseases can mimic each other and the coexistence of both diseases in the same patient has been reported. Given that BD and FMF have similar pathophysiological, epidemiological, and clinical features, we hypothesized that the gene responsible for FMF, MEFV, may also play a role in the pathogenesis of BD.