Deoxycholate hydrogels of betamethasone-17-valerate intended for topical use: In vitro and in vivo evaluation

Senyigit T., Tekmen I., Sonmez Ü., Santi P., Ozer O.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.403, ss.123-129, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 403
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.ijpharm.2010.10.036
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-129
  • Anahtar Kelimeler: Betamethasone valerate, Sodium-deoxycholate gel, Texture profile analysis, Skin permeation enhancement, Anti-inflammatory activity, MECHANICAL CHARACTERIZATION, MUCOADHESIVE PROPERTIES, PERMEATION ENHANCEMENT, TRANSDERMAL DELIVERY, DRUG-DELIVERY, ANIMAL-MODELS, EX-VIVO, FORMULATION, SKIN, PENETRATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the suitability of sodium-deoxycholate (Na-DOC) gels containing betamethasone-17-valerate (BMV) for topical application. The gels were characterized for rheological and textural properties. The in vitro flux of BMV from Na-DOC gels across rat skin was 2.5 (0.05% gel) and 8.5 times (0.1% gel) higher compared to the commercial cream (0.1%), respectively. The pharmacodynamic responses after in vivo topical application in rats were also determined. A significant correlation between anti-inflammatory activity and in vitro permeation of BMV was observed. Na-DOC gels produced significantly higher edema inhibition compared to commercial cream at all time intervals. Finally, according to the results of histology studies, Na-DOC gel has no irritant effect on the skin.