Reduction of postoperative adhesions by trimetazidine: an experimental study in a rat model

ERDEMOĞLU E., Seckin B., GÜNYELİ İ., GÜNEY M., Seckin M., Mungan T.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.285, sa.3, ss.757-761, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 285 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00404-011-2072-x
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.757-761
  • Anahtar Kelimeler: Intraabdominal adhesion, Trimetazidine, Ischemia, Antioxidants
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Trimetazidine (TMZ) reduces intracellular acidosis and inhibits oxygen-derived free radicals and neutrophile infiltration in ischemia and hypoxia, which are the primary steps of adhesion formation. Our aim is to study the anti-adhesion potential of trimetazidine in a rat uterine horn model.