Reduction of postoperative adhesions by trimetazidine: an experimental study in a rat model

ERDEMOĞLU E., Seckin B., GÜNYELİ İ., GÜNEY M., Seckin M., Mungan T.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.285, no.3, pp.757-761, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 285 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1007/s00404-011-2072-x
  • Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.757-761
  • Keywords: Intraabdominal adhesion, Trimetazidine, Ischemia, Antioxidants, UTERINE HORN MODEL, PERITONEAL FIBRINOLYTIC-ACTIVITY, PREVENTION, MELATONIN, ANGINA
  • Dokuz Eylül University Affiliated: No

Abstract

Trimetazidine (TMZ) reduces intracellular acidosis and inhibits oxygen-derived free radicals and neutrophile infiltration in ischemia and hypoxia, which are the primary steps of adhesion formation. Our aim is to study the anti-adhesion potential of trimetazidine in a rat uterine horn model.